Comparison of the efficacy and safety of insulin detemir administered once daily according to two titration algorithms 3 0 3 and 2 4 6 8 in patients with type 2 diabetes mellitus. The journal of clinical endocrinology metabolism is the worlds leading peer reviewed journal for the dissemination of original research as it relates to the clinical practice of endocrinology diabetes and metabolism spanning the full spectrum of translational research from discovery science to experimental medicine and from critical evaluation of new treatments to patient population . The american journal of physiology endocrinology and metabolism publishes original mechanistic studies on the physiology of endocrine and metabolic systems physiological cellular and molecular studies in whole animals or humans will be considered. Endocrinology and metabolism research since its establishment basic and clinical research have been an integral part of the mission of northwestern medicine northwestern medicine physicians are national leaders in many areas of clinical research. In the present issue of the journal of clinical endocrinology and metabolism tirosh and colleagues examined the consequences of hypercortisolism on the brain of young patients with cushing syndrome cs using magnetic resonance imaging they showed that changes in white matter and gray matter wm gm consistency
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